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I. Radioisotope Generator, RG

A. Cyclotron – Charged particles (H^- ion) in magnetic field accelerated by a rapidly varying electric field outwards from the center along a spiral path as a particle accelerator

l  Model – PETtrace 10

l  Manufacturer – GE Healthcare System

l  Introduction – 2011. 07.

l  Accelerating Particle – Proton, Deuteron

l  Energy – Proton 16.5 MeV, Deuteron 8.4 MeV

l  Beam Output Current – 100 µA

l  Ion Source Type – H^-, D^-

l  Target Positions – 6 Targets (¹⁸F, ¹³N, ¹⁵O, ⁶⁴Cu, ¹²⁴I, ¹¹CO₂)

l  Beam Extraction – Carbon Foil

B.  ⁶⁸Ge/⁶⁸Ga Generator - A device used to extract the positron-emitting isotope ⁶⁸Ga from a source of decaying ⁶⁸Ge. The parent isotope ⁶⁸Ge has a half of 271 days and can be easily utilized for in-hospital production of generator produced ⁶⁸Ga.

lI. Radiopharmaceutical Synthesizer

A. GEFastlab^TM 2 synthesizer

l  Fastlab^TM 2 is a compact automated system that converts externally produced radio-isotopes(from cyclotron) into radiochemicals ready for further processing and quality control

l  Radiopharmaceuticals

[¹⁸F]FDG (Phosphate, Duo Citrate) / [¹⁸F]NaF / [¹⁸F]FMISO / [¹⁸F]FLT 

B. GE Tracerlab MX (Only Use for Cassette type)

l  Radiopharmaceuticals

[¹⁸F]FDG / [¹⁸F]FDOPA / [¹⁸F]NaF / [¹⁸F]FMISO / [¹⁸F]FLT 

C. GE Tracerlab FX-FN (Only use for research)

Ø  [¹⁸F]FCH / [¹⁸F]FDOPA / [¹⁸F]FTHA / [¹⁸F]FMISO / [¹⁸F]FLT

D. GE Tracerlab FXc Pro

l  FXc Pro is a compact, automated radiochemistry system, which will produce C-11 labeled radiochemicals from [¹¹C]MeI or [¹¹C]MEOTf

l  Radiopharmaceuticals

[¹¹C]Methionine / [¹¹C]Raclopride / [¹¹C]FMZ / [¹¹C]PIB / [¹¹C]Acetate / [¹¹C]ABP688 / [¹¹C]PBR28 / [¹¹C]DASB / [¹¹C]PK11195 / [¹¹C]Sertraline / [¹¹C]Verapamil  

E. Soild Target Processing System ALCEO

l  Radioisotope

[⁶²Zn] / [⁶⁴Cu] / [⁸⁹Zr] / [¹²⁴I]

F. N-13 Ammonia Process Unit

l  Radiopharmaceutical

[¹³N]Ammonia 

G. O-15 Water Process Unit

l  Radiopharmaceutical

Ø  [¹⁵O]Water

H. Ga-68 Process Unit (SNUH in House)

l  Radiopharmaceuticals

Ø  [⁶⁸Ga]NOTA-TOC / [⁶⁸Ga]NOTA-RGD

3. Quality Control

All quality controls completed before patient injection except for sterility test

Ø  Appearance

Ø  Filter Integrity Test(FIT SNUH in House)

Ø  Bacterial Endotoxin Test(PTS)

Ø  Kryptofix2.2.2 Spot Test

Ø  pH(pH Meter or pH Paper)

Ø  Radiochemical Purity(TLC)

Ø  Energy Spectrum(MCA)

Ø  Residual Solvent(GC)

Ø  Half-Life Determination(Dose Calibrator)

ØSterility Test(FTM, TSB) 

4. Analytical Equipment

A. High Performance Liquid Chromatography(HPLC)

Ø  Model – HPLC System

Ø  Manuf. – Gilson, Inc.

Ø  Introduction – 2011.

Ø  Pump – Binary

Ø  Detector – 155 UV/VIS, NaI Scintillation(Raytest)

Ø Prep 3EA, Anal 3EA

B. Gas Chromatography(GC)

Ø  Model – 7820A GC System

Ø  Manuf. – Agilent Technologies

Ø  Introduction – 2011.

Ø  Detector – FID

Ø  2EA

C. Thin Layer Chromatography(TLC)

Ø  Model – AR-2000-1

Ø  Manuf. – Bioscan, Inc.

Ø  Introduction – 2014.

Ø  Detector – P10 Gas-Filled Proportional Counter

Ø 2EA     

D. Portable Testing System(Endosafe^®-PTS™)

Ø  Model – Endosafe^® PTS KINETIC READER

Ø  Manuf. – Charles River Laboratories

Ø  Introduction – 2011.

Ø  Sensitivity – 5~0.05 EU/mL

Ø 2EA 

E.  Filter Integrity Tester

Ø  Model – Filter Integrity tester

Ø  Manuf. – SNUH in-house

Ø  Introduction – 2016.

Ø 1EA 

F. Multi-Channel Analyzer(MCA)

Ø  Model – Genie^TM 2000 Spectroscopy

Ø  Manuf. – CANBERRA Industries, Inc.

Ø  Introduction – 2014.

Ø  Detector – High Performance Germanium

Ø  1EA